YOUTUBE DNA BEHAVIOR STYLES INITIATER SKIN

YOUTUBE DNA BEHAVIOR STYLES INITIATER SKIN

At 48 h after dermal application, significantly higher levels of urethane remained bound to skin DNA, RNA, and protein in BALB/c mice, although all values were lower than at 6 h after treatment. Dermal application of urethane resulted in severalfold higher binding to liver DNA of SENCAR mice than BALB/c mice, but DNA binding was comparable in other tissues after 6 h. Binding to DNA in skin, lung, and stomach, RNA in stomach, and protein in stomach and liver after 48 h were significantly higher in SENCAR mice than in BALB/c mice. Binding of urethane (0.062 mg/g body weight, 20 μCi/20 g body weight) to DNA, RNA, and protein 6 h after oral administration varied with tissue (liver > stomach > skin = lung) but did not differ with strain. Following dermal application, higher levels were maintained in the liver, lungs, and stomach through 48 h in the SENCAR mice when compared to BALB/c mice. These differences were not observed at later time periods after oral administration.

Absorption of urethane was greater in the first hour in SENCAR mice by both routes, as indicated by more label in the liver, lung, and stomach than found in these tissues in BALB/c mice. To better understand the relation of distribution to the initiation stage, urethane (0.10 mg/kg, 2.5 μCi/25 g) was administered orally and dermally to male SENCAR and BALB/c mice. Urethane produces threefold more skin papillomas when administered orally than dermally in SENCAR mice, a strain susceptible to tumorigenesis.

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